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首页-抗体和重组蛋白-Biosimilar Antibody-Tarlatamab
Tarlatamab

Chemical Structure : Tarlatamab

CAS No.: 2307488-83-9

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Tarlatamab (AMG 757)

货号: PC-38870Not For Human Use, Lab Use Only.

Tarlatamab (AMG 757) is a half-life extended bispecific T-cell engager (BiTE) molecule targeting delta-like ligand 3 (DLL3), a target that is selectively expressed in SCLC tumors, but with minimal normal tissue expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Tarlatamab (AMG 757) is a half-life extended bispecific T-cell engager (BiTE) molecule targeting delta-like ligand 3 (DLL3), a target that is selectively expressed in SCLC tumors, but with minimal normal tissue expression.
AMG 757 showed potent and specific killing of even those SCLC cell lines with very low DLL3 expression (<1,000 molecules per cell).
AMG 757 effectively engaged systemically administered human T cells, induced T-cell activation, and redirected T cells to lyse tumor cells to promote significant tumor regression and complete responses in PDX models of SCLC and in orthotopic models of established primary lung SCLC and metastatic liver lesions.

Isotype: Immunoglobulin scFv-scFv-scFc.

Anti-[huuman DLL3 (deltalike ligand 3)] and anti-[human CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Giffin MJ, et al. Clin Cancer Res. 2021 Mar 1;27(5):1526-1537.

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