TNIK inhibitor X | TNIK inhibitor | Probechem Biochemicals

Chemical Structure : TNIK inhibitor X

CAS No.: 933886-36-3

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TNIK inhibitor X (TNIK-IN-1)

货号: PC-36010Not For Human Use, Lab Use Only.

TNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled.

规格	价格	库存
5 mg	￥4780	In stock
10 mg	￥7580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

TNIK inhibitor X is a potent inhibitor of Traf2- and Nck-interacting kinase (TNIK) (in vitro enzyme IC50=9 nM) with a reasonable selectivity over 30-folds against the majority of a panel of 50 kinases profiled.
TNIK inhibitor X inhibits cell viability of PAMC82 and T47D cells harboring TNIK amplification with IC50 of 1.77 and 0.385 uM, respectively.
TNIK inhibitor X shows no inhibitory activity against TNIK-non-amplified AZ-521 cells (IC50>30 uM).
TNIK inhibitor X suppresses pAKT and induction of LC3 in TNIK-amplified PAMC82 cells, shows minimal effects on either Wnt signaling-mediated transcription.

物理化学性质&存储条件

分子量	395.437
分子式	C19H17N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-acetamidobenzamido)-2-(phenylamino)thiazole-4-carboxamide

参考文献

1. Yu DH, et al. Oncogenesis. 2014 Feb 24;2:e89.

2. Yamada T, et al. TNIK inhibitor and the use. W02010/064111A1.

TNIK inhibitor X (TNIK-IN-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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TNIK inhibitor X (TNIK-IN-1)

生物&药学活性

物理化学性质&存储条件

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