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首页-小分子抑制剂&激动剂-Epigenetics-MicroRNA-TGP-377
TGP-377

Chemical Structure : TGP-377

CAS No.: 2665700-67-2

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TGP-377 (TGP377, Targapre-miR-377)

货号: PC-72389Not For Human Use, Lab Use Only.

TGP-377 (TGP377, Targapre-miR-377) is a small molecule that specifically and potently enhances VEGFA expression by the targeting pre-miR-377 that regulates its expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TGP-377 (TGP377, Targapre-miR-377) is a small molecule that specifically and potently enhances VEGFA expression by the targeting pre-miR-377 that regulates its expression.
    TGP-377 binds to miR-377's Dicer processing site with Kd of 190 nM, potently and specifically upregulate VEGFA in human umbilical vein endothelial cells.
    TGP-377 potently and selectively inhibits pre-miR-377 biogenesis, stimulating VEGFA, increases pre-miR-377 levels by 1.6-fold when HUVECs were treated with 500 nM of TGP-377.
    TGP-377 exerts selective effects on the proteome and indeed broadly affects signalling through the VEGFA pathway.
    TGP-377 (500 nM) increased tubule branching density by 50% in HUVECs.

    物理化学性质&存储条件

    分子量 1428.723
    分子式 C75H93N23O7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-(5-amino-1H-benzo[d]imidazol-2-yl)-5-(6-amino-1H-benzo[d]imidazol-2-yl)phenoxy)-N-(12-(2-amino-2-oxoethyl)-15-(4-((4-(2-methyl-6-((4-(quinolin-2-ylamino)pyridin-2-yl)amino)pyrimidin-4-yl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2,5,8,11-tetraoxo-3,6,9-tripropyl-3,6,9,12-tetraazapentadecyl)-N-propylbutanamide

    参考文献

    1. Hafeez S Haniff, et al. Nat Chem. 2020 Oct;12(10):952-961.

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