T247 |CAS:1451042-18-4 Probechem Biochemicals

Chemical Structure : T247

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T247 (T 247;HDAC3 inhibitor T247)

货号: PC-60827Not For Human Use, Lab Use Only.

T247 is a potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

T247 is a potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
T247 induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells.
T247 shows promising activity for anticancer and antiviral benefits.
T247 also decreases TMEM16A expression and functional activity in both prostatic cancer cell line PC-3 and the breast cancer cell line YMB-1.

物理化学性质&存储条件

分子量	389.477
分子式	C21H19N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)-1H-[1],[2],[3]triazol-4-yl]benzamide

参考文献

1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669.

2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8.

3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.

T247 (T 247;HDAC3 inhibitor T247)

生物&药学活性

物理化学性质&存储条件

参考文献

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T247 (T 247;HDAC3 inhibitor T247)

生物&药学活性

物理化学性质&存储条件

参考文献

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