Surfen | Heparan sulfate antagonist |Probechem Biochemicals

Chemical Structure : Surfen

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Surfen (Aminoquinuride)

货号: PC-62072Not For Human Use, Lab Use Only.

Surfen is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.

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生物&药学活性

Surfen is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.
Surfen neutralizes the ability of the various heparins to activate antithrombin and inactivate Factor Xa.
Surfen blocks sulfation and degradation of GAG chains in vitro and alters cellular responses dependent on HS such as growth factor binding and activation, cell attachment, viral infection by HSV, and angiogenesis.
Surfen also can blocks C5a receptor binding and lethal factor produced by anthrax.

物理化学性质&存储条件

分子量	372.432
分子式	C21H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-bis(4-amino-2-methylquinolin-6-yl)urea

参考文献

1. Schuksz M, et al. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.

2. Lanza TJ, et al. J Med Chem. 1992 Jan 24;35(2):252-8.

3. Panchal RG, et al. Nat Struct Mol Biol. 2004 Jan;11(1):67-72.

4. Roan NR, et al, J Biol Chem. 2010 Jan 15;285(3):1861-9.

Surfen (Aminoquinuride)

生物&药学活性

物理化学性质&存储条件

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Surfen (Aminoquinuride)

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物理化学性质&存储条件

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