Sudapyridine (WX-081) | Antituberculosis | Probechem Biochemicals

Chemical Structure : Sudapyridine

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Sudapyridine (WX-081, WX081)

货号: PC-49162Not For Human Use, Lab Use Only.

Sudapyridine (WX-081) is a potential new antituberculosis compound,excellent antimicrobial in vitro activity against both drug-susceptible and drug-resistant M. tuberculosis clinical isolates with MICs of 0.117 to 0.219 ug/mL.

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生物&药学活性

Sudapyridine (WX-081) is a potential new antituberculosis compound,excellent antimicrobial in vitro activity against both drug-susceptible and drug-resistant M. tuberculosis clinical isolates with MICs of 0.117 to 0.219 ug/mL.
WX-081 demonstrates similar or minor weakness in vitro activity against TB drug-resistant clinical isolates of M. tuberculosis, including isoniazid, rifampin, streptomycin, ethambutol, and moxifloxacin.
WX-081 retaines activity against MDR-TB strains at <1 ug/mL.
WX-081 has good in vitro activity against clinically isolated strains of Mycobacterium tuberculosis, including sensitive strains and drug-resistant strains.
WX-081 demonstrates vivo efficacy in the acute mouse infection model at at 10 mg/kg.

物理化学性质&存储条件

分子量	537.100
分子式	C34H33ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S)-1-(5-(4-chlorophenyl)-2-methoxypyridin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

参考文献

1. Yao R, et al. Microbiol Spectr. 2022 Feb 23;10(1):e0247721.

2. Huang Z, et al. Bioorg Med Chem Lett. 2022 Sep 1;71:128824.

Sudapyridine (WX-081, WX081)

生物&药学活性

物理化学性质&存储条件

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Sudapyridine (WX-081, WX081)

生物&药学活性

物理化学性质&存储条件

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