欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-抗体和重组蛋白-Biosimilar Antibody-Simtuzumab
Simtuzumab

Chemical Structure : Simtuzumab

CAS No.: 1318075-13-6

加入收藏

Simtuzumab (Anti-human LOXL2 mAb, human IgG4-Kappa; GS-6624)

货号: PC-Ab1092Not For Human Use, Lab Use Only.

Simtuzumab (SIM, GS-6624) is a humanized IgG1 antibody against lysyl oxidase like-2 (LOXL2). Simtuzumab binds to LOXL2, was shown to have a role in suppressing bleomycin-induced pulmonary fibrosis in a murine model. pecifically target and block the LOXL2 which has been assigned to an important role in fibrosis. Besidesm, LOXL2 is one of several secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. It is widely expressed, particularly in placenta, uterus, and

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Simtuzumab (SIM, GS-6624) is a humanized IgG1 antibody against lysyl oxidase like-2 (LOXL2). Simtuzumab binds to LOXL2, was shown to have a role in suppressing bleomycin-induced pulmonary fibrosis in a murine model. pecifically target and block the LOXL2 which has been assigned to an important role in fibrosis. Besidesm, LOXL2 is one of several secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. It is widely expressed, particularly in placenta, uterus, and prostate. LOXL2 is upregulated during cancer progression and promotes cell migration and tumor cell invasiveness.

物理化学性质&存储条件

分子量
分子式 Human IgG4-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Simtuzumab; GS-6624; GS6624; 1318075-13-6; Anti-human Lysyl oxidase homolog 2; Anti-human LOXL2

参考文献

1. 1, Harrison SA, et al. Gastroenterology. 2018 Oct;155(4):1140-1153. 2, Muir AJ, et al. Hepatology. 2019 Feb;69(2):684-698. 3, Meissner EG, et al. Liver Int. 2016 Dec;36(12):1783-1792.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: