Semaxinib (SU5416) | VEGFR2 inhibitor Probechem Biochemicals

Chemical Structure : Semaxinib (SU5416)

CAS No.: 204005-46-9

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Semaxinib (SU5416) (SU-5416, SU 5416)

货号: PC-42557Not For Human Use, Lab Use Only.

Semaxinib (SU5416) is a potent and specific VEGFR2 (KDR/Flk-1) inhibitor with IC50 of 1.04 uM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

Semaxinib (SU5416) is a potent and specific VEGFR2 (KDR/Flk-1) inhibitor with IC50 of 1.04 uM.
Semaxinib (SU5416) displays no inhibitory activity against EGFR and FGFR.
Semaxinib (SU5416) inhibits autophosphorylation of the Flk-1 receptor with IC50 of 1.23 uM in ELISA assays, inhibits VEGF-driven mitogenesis of HUVECs with IC50 of 0.04 uM.
Semaxinib (SU5416) affects tumor vascular density and vascular leakage in vivo.

物理化学性质&存储条件

分子量	238.2845
分子式	C15H14N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 22.5 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-

参考文献

1. Fong TA, et al. Cancer Res. 1999 Jan 1;59(1):99-106.

2. Shaheen RM, et al. Cancer Res. 1999 Nov 1;59(21):5412-6.

3. Mendel DB, et al. Anticancer Drug Des. 2000 Feb;15(1):29-41.

4. Mendel DB, et al. Clin Cancer Res. 2000 Dec;6(12):4848-58.

Semaxinib (SU5416) (SU-5416, SU 5416)

生物&药学活性

物理化学性质&存储条件

参考文献

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Semaxinib (SU5416) (SU-5416, SU 5416)

生物&药学活性

物理化学性质&存储条件

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