Chemical Structure : Selicrelumab
CAS No.: 1622140-49-1
货号: PC-Ab1039Not For Human Use, Lab Use Only.
Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth.
分子量 | ||
分子式 | Human IgG2-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Selicrelumab; RO 7009789; RG 7876; CP-870,893; Cluster of Differentiation 40; CD40/TNFR5; 1622140-49-1; CD40-CD40L agonist antibody. |
1. 1, Byrne KT, et al. Clin Cancer Res. 2021 Aug 15;27(16):4574-4586. 2, Delgado R, et al. Cancers (Basel). 2021 Jun 21;13(12):3084. 3, Djureinovic D, et al. Cancers (Basel). 2021 Mar 15;13(6):1302. 4, Machiels JP, et al. J Immunother Cancer. 2020 Oct;8(2):e001153.
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