欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-抗体和重组蛋白-Biosimilar Antibody-Selicrelumab
Selicrelumab

Chemical Structure : Selicrelumab

CAS No.: 1622140-49-1

加入收藏

Selicrelumab (Anti-human CD40 mAb, human IgG2-Kappa; RO 7009789; RG 7876)

货号: PC-Ab1039Not For Human Use, Lab Use Only.

Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth.

物理化学性质&存储条件

分子量
分子式 Human IgG2-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Selicrelumab; RO 7009789; RG 7876; CP-870,893; Cluster of Differentiation 40; CD40/TNFR5; 1622140-49-1; CD40-CD40L agonist antibody.

参考文献

1. 1, Byrne KT, et al. Clin Cancer Res. 2021 Aug 15;27(16):4574-4586. 2, Delgado R, et al. Cancers (Basel). 2021 Jun 21;13(12):3084. 3, Djureinovic D, et al. Cancers (Basel). 2021 Mar 15;13(6):1302. 4, Machiels JP, et al. J Immunother Cancer. 2020 Oct;8(2):e001153.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: