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首页-抗体和重组蛋白-Biosimilar Antibody-Selicrelumab
Selicrelumab

Chemical Structure : Selicrelumab

CAS No.: 1622140-49-1

Selicrelumab (Anti-human CD40 mAb, human IgG2-Kappa; RO 7009789; RG 7876)

货号: PC-Ab1039Not For Human Use, Lab Use Only.

Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Selicrelumab (RO 7009789) is a fully humanized monoclonal IgG2 antibody that binds CD40 with a very high affinity (Kd=0.4 nM). Selicrelumab does not bind the same site as natural CD40L and hence does not block the natural CD40L-CD40 interaction. Selicrelumab binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B-cells and T-cells, resulting in an enhanced immune response. Selicrelumab also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth.

物理化学性质&存储条件

分子量
分子式 Human IgG2-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

Selicrelumab; RO 7009789; RG 7876; CP-870,893; Cluster of Differentiation 40; CD40/TNFR5; 1622140-49-1; CD40-CD40L agonist antibody.

参考文献

1. 1, Byrne KT, et al. Clin Cancer Res. 2021 Aug 15;27(16):4574-4586. 2, Delgado R, et al. Cancers (Basel). 2021 Jun 21;13(12):3084. 3, Djureinovic D, et al. Cancers (Basel). 2021 Mar 15;13(6):1302. 4, Machiels JP, et al. J Immunother Cancer. 2020 Oct;8(2):e001153.

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