Sarcomere inhibitor W7

Chemical Structure : Sarcomere inhibitor W7

CAS No.: 65595-90-6

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货号: PC-38788Not For Human Use, Lab Use Only.

Sarcomere inhibitor W7 is a small-molecule sarcomere Ca2+ desensitizer, decreases intact cardiac myocyte contractility in a Ca2+ transient amplitude-independent manner.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Sarcomere inhibitor W7 is a small-molecule sarcomere Ca2+ desensitizer, decreases intact cardiac myocyte contractility in a Ca2+ transient amplitude-independent manner.
W7 binds to cardiac troponin C (cTnC) and decrease Ca2+-binding affinity, resulting in Ca2+ desensitization of the myofilament.
W7 reduces contractility in a Ca2+-independent manner in adult living cardiac myocytes.
W7 exihibits a rapid effect to correct contractile dysfunction in both acquired (alkalosis) and inherited (RCM) forms of hyper-Ca2+-sensitive states at the myocyte level and whole heart levels.

物理化学性质&存储条件

分子量	340.866
分子式	C16H21ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide

参考文献

1. Thompson BR, et al. Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H36-43.

2. Cai F, et al. Biochemistry. 2018 Nov 20;57(46):6461-6469.