SW IV-134

Chemical Structure : SW IV-134

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货号: PC-72363Not For Human Use, Lab Use Only.

SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52, induces degradation of cIAP-1 and cIAP-2.

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生物&药学活性

SW IV-134 is a sigma-2/SMAC drug conjugate, chemically linked the sigma-2 ligand SW43 to the Smac mimetic SW IV-52, induces degradation of cIAP-1 and cIAP-2.
SW IV-134 slowed tumor growth and improved survival in murine models of pancreatic cancer.
SW IV-134 significantly reduced tumor burden and improved overall survival in a mouse xenograft model of ovarian cancer without causing significant adverse effects to normal tissues.
SW IV-134 induced degradation of cIAP-1 and cIAP-2 leading to NF-kB activation and TNFα-dependent cell death.

物理化学性质&存储条件

分子量	871.221
分子式	C51H78N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(10-(((S)-1-(((S)-3,3-dimethyl-1-oxo-1-((S)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)butan-2-yl)amino)-1-oxopropan-2-yl)amino)decyl)-9-azabicyclo[3.3.1]nonan-3-yl (2-methoxy-5-methylphenyl)carbamate

参考文献

1. Garg G, et al. Mol Cancer. 2014 Mar 7;13:50.

2. Hashim YM, et al. Mol Oncol. 2014 Jul;8(5):956-67.

3. Hashim YM, et al. J Exp Clin Cancer Res. 2017 Jan 17;36(1):14.

4. Oost TK, et al. J Med Chem. 2004;47:4417–4426.

SW IV-134

生物&药学活性

物理化学性质&存储条件

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SW IV-134

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