STOML3 inhibitor OB-1 |CAS:300803-69-4 Probechem Biochemicals

Chemical Structure : STOML3 inhibitor OB-1

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STOML3 inhibitor OB-1

货号: PC-61244Not For Human Use, Lab Use Only.

STOML3 inhibitor OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

STOML3 inhibitor OB-1 is a small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo.
OB-1 effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin.
OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
OB-1 also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.

物理化学性质&存储条件

分子量	407.382
分子式	C21H17N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate

参考文献

1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218.