SR-16157 |CAS:943344-76-1 Probechem Biochemicals

Chemical Structure : SR-16157

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SR-16157 (NSC 732011;SR16157;HLX 801)

货号: PC-61433Not For Human Use, Lab Use Only.

A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM).

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生物&药学活性

A novel dual-acting steroid sulfatase inhibitor (IC50=0.1 uM) and selective ERα modulator (SERM); exerts STS inhibition and antiestrogenic effects, 10 times more potent than the antiestrogens SR-16137 and tamoxifen in cell growth and ERα function test in MCF-7 breast cancer cells; displays profoundly improved ERα binding affinity and antiestrogenic effects on expression of estrogen-regulated genes.

Breast Cancer

Phase 2 Clinical

物理化学性质&存储条件

分子量	492.719
分子式	C27H44N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7R,17R)-17-(2-(2-(diethylamino)ethoxy)ethyl)-7,13-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl sulfamate

参考文献

1. Rasmussen LM, et al. Breast Cancer Res Treat. 2007 Dec;106(2):191-203.

2. Rausch L, et al. Cancer Chemother Pharmacol. 2011 Jun;67(6):1341-52.

3. Wang J, et al. J Pharm Biomed Anal. 2007 Nov 30;45(4):572-82.

SR-16157 (NSC 732011;SR16157;HLX 801)

生物&药学活性

物理化学性质&存储条件

参考文献

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SR-16157 (NSC 732011;SR16157;HLX 801)

生物&药学活性

物理化学性质&存储条件

参考文献

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