SPD-304 | TNFα inhibitor | Probechem Biochemicals

Chemical Structure : SPD-304

CAS No.: 869998-49-2

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SPD-304 (TNFα inhibitor X, SPD304)

货号: PC-61313Not For Human Use, Lab Use Only.

SPD-304 is an inhibitor of tumor necrosis factor α (TNFα) that prevents binding to the TNF Receptor 1 (TNFR1) with IC50 of 22 uM.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

SPD-304 (TNFα inhibitor X) is an inhibitor of tumor necrosis factor α (TNFα) that prevents binding to the TNF Receptor 1 (TNFR1) with IC50 of 22 uM.
SPD-304 (TNFα inhibitor X) binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine.
SPD-304 (TNFα inhibitor X) inhibits TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 uM in a cell based assay.

物理化学性质&存储条件

分子量	547.622
分子式	C32H32F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethyl-3-((methyl(2-(methyl((1-(3-(trifluoromethyl)phenyl)-1H-indol-3-yl)methyl)amino)ethyl)amino)methyl)-4H-chromen-4-one

参考文献

1. He MM, et al. Science. 2005 Nov 11;310(5750):1022-5.

2. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.

3. Blevitt JM, et al. J Med Chem. 2017 Apr 27;60(8):3511-3517.

SPD-304 (TNFα inhibitor X, SPD304)

生物&药学活性

物理化学性质&存储条件

参考文献

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SPD-304 (TNFα inhibitor X, SPD304)

生物&药学活性

物理化学性质&存储条件

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