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首页-小分子抑制剂&激动剂-GPCR-Melanocortin Receptor-SHU-9119
SHU-9119

Chemical Structure : SHU-9119

CAS No.: 168482-23-3

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SHU-9119 (SHU9119)

货号: PC-70059Not For Human Use, Lab Use Only.

SHU-9119 is a potent melanocortin MC3 and MC4 receptor antagonist with IC50 of 0.23 nM and 0.06 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SHU-9119 is a potent melanocortin MC3 and MC4 receptor antagonist with IC50 of 0.23 nM and 0.06 nM, respectively.
SHU-9119 also is an MC5R partial agonist (EC50 = 0.12 nM).
SHU-9119 upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACCα and FAS), increases triglyceride synthesis and promotes insulin resistance.
SHU-9119 increases food intake, body weight and fat mass when administered centrally in vivo.

物理化学性质&存储条件

分子量 1074.258
分子式 C54H71N15O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Nle(Ac)-cyclo(Asp-His-D-2-Nal-Arg-Trp-Lys)-NH2

参考文献

1. Hruby VJ, et al. J Med Chem. 1995 Sep 1;38(18):3454-61.

2. Fan W, et al. Nature. 1997 Jan 9;385(6612):165-8.

3. Huang QH, et al. J Neurosci. 1997 May 1;17(9):3343-51.

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