SGI-110 |CAS:929901-49-5 Probechem Biochemicals

Chemical Structure : SGI-110

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SGI-110 (SGI 110;SGI110;Guadecitabine)

货号: PC-60765Not For Human Use, Lab Use Only.

SGI-110 (Guadecitabine) is a novel DNA hypomethylating dinucleotide that inhibits DNA methyltransferase (DNMT).

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生物&药学活性

SGI-110 (Guadecitabine) is a novel DNA hypomethylating dinucleotide that inhibits DNA methyltransferase (DNMT).
SGI-110 induces/up-regulates the expression of investigated cancer/testis antigens in broad cancer cell lines, both at mRNA and at protein levels.
SGI-110 reduces the stem-like properties of ALDH(+) ovarian cancer stem-like cells, including their tumor-initiating capacity, resensitizes these OCSCs to platinum.
SGI-110 induces hypomethylation and CTA gene expression in a dose dependent manner both in vitro and in vivo.

物理化学性质&存储条件

分子量	557.41
分子式	C18H24N9O10P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2S,3R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate

参考文献

1. Wang Y, et al. Cancer Res. 2014 Sep 1;74(17):4922-36.

2. Srivastava P, et al. Epigenetics. 2015;10(3):237-46.

3. Srivastava P, et al. Leuk Res. 2014 Nov;38(11):1332-41.

4. Fang F, et al. Clin Cancer Res. 2014 Dec 15;20(24):6504-16.

SGI-110 (SGI 110;SGI110;Guadecitabine)

生物&药学活性

物理化学性质&存储条件

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SGI-110 (SGI 110;SGI110;Guadecitabine)

生物&药学活性

物理化学性质&存储条件

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