SF-1126 |CAS:936487-67-1 Probechem Biochemicals

Chemical Structure : SF-1126

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SF-1126 (SF 1126;SF1126)

货号: PC-60413Not For Human Use, Lab Use Only.

SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins.

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1 g		Get quote

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生物&药学活性

SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins; blocks expression levels of c-Myc in HCC cells, inhibits proliferation, cell cycle, apoptosis, PI3K/AKT/mTOR and Ras/Raf/MAPK pathway; shows significant antitumor activity in vivo.

Liver Cancer

Phase 1 Clinical

物理化学性质&存储条件

分子量	852.84
分子式	C39H48N8O14
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-oxo-4-((4-(4-oxo-8-phenyl-4H-chromen-2-yl)morpholino-4-ium)methoxy)butanoyl)-L-arginylglycyl-L-aspartyl-L-serinate

参考文献

1. Garlich JR, et al. Cancer Res. 2008 Jan 1;68(1):206-15.

2. Dittmann A, et al. ACS Chem Biol. 2014 Feb 21;9(2):495-502.

3. Erdreich-Epstein A, et al. Oncotarget. 2016 Nov 16. doi: 10.18632/oncotarget.13386.

SF-1126 (SF 1126;SF1126)

生物&药学活性

物理化学性质&存储条件

参考文献

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SF-1126 (SF 1126;SF1126)

生物&药学活性

物理化学性质&存储条件

参考文献

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