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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-S-217622
S-217622

Chemical Structure : S-217622

CAS No.: 2647530-73-0

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S-217622 (Ensitrelvir, S217622)

货号: PC-38178Not For Human Use, Lab Use Only.

S-217622 (Ensitrelvir, S217622) is the first oral, non-covalent, non-peptidic SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate with biochemical IC50 of 13 nM, antiviral EC50 of 0.37 uM.

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50 mg ￥1480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

S-217622 (Ensitrelvir, S217622) is the first oral, non-covalent, non-peptidic SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate with biochemical IC50 of 13 nM, antiviral EC50 of 0.37 uM.
The antiviral activity of S-217622 against SARS-CoV and SARS-CoV-2 was similar especially at the site where homology of 3CLpro was well conserved.
S-217622 also exhibited potent antiviral ability against the Middle East respiratory syndrome (MERS), human coronavirus OC43 (HCoV-OC43), and human coronavirus 229E (HCoV-229E).
S-217622 exhibited no inhibitory effect against host-cell proteases, such as cathepsin B/D/G/L, caspase-2, chymotrypsin, and thrombin at 100 uM.
S-217622 dose-dependently inhibited intrapulmonary replication of SARS-CoV-2 in mice, and currently under clincial investigation for COVID-19.

物理化学性质&存储条件

分子量 531.884
分子式 C22H17ClF3N9O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO (5.3 mg/mL)
Chemical Name/SMILES

1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)-

参考文献

1. Yuto Unoh, et al. bioRxiv 2022.01.26.477782.

2. Kawaoka Y, et al. Res Sq. 2022 Feb 24:rs.3.rs-1375091.

3. McKimm-Breschkin JL, et al. Antiviral Res. 2022 Jan;197:105227.

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