RAD51 inhibitor B02 |CAS:1290541-46-6 Probechem Biochemicals

Chemical Structure : RAD51 inhibitor B02

CAS No.: 1290541-46-6

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RAD51 inhibitor B02 (Compound B02)

货号: PC-62842Not For Human Use, Lab Use Only.

RAD51 inhibitor B02 is a small molecule that specifically inhibits the DNA strand exchange activity of human RAD51 with IC50 of 27.4 uM, disrupts RAD51 binding to DNA, inhibits HR and increases cell sensitivity to DNA damage.

规格	价格	库存
25 mg	￥1980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

RAD51 inhibitor B02 is a small molecule that specifically inhibits the DNA strand exchange activity of human RAD51 with IC50 of 27.4 uM, disrupts RAD51 binding to DNA, inhibits HR and increases cell sensitivity to DNA damage.
RAD51 inhibitor B02 increases apoptosis and reduces viability of multiple myeloma cells.
RAD51 inhibitor B02 enhances the effect of cisplatin on triple-negative breast cancer cells in a mouse xenograft model.

物理化学性质&存储条件

分子量	339.4
分子式	C22H17N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

参考文献

1. Huang F, et al. J Med Chem. 2012 Apr 12;55(7):3011-20.

2. Huang F, et al. ACS Chem Biol. 2011 Jun 17;6(6):628-35.

3. Huang F, et al. PLoS One. 2014 Jun 27;9(6):e100993.

RAD51 inhibitor B02 (Compound B02)

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物理化学性质&存储条件

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RAD51 inhibitor B02 (Compound B02)

生物&药学活性

物理化学性质&存储条件

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