RA5557 | UGT8 inhibitor | Probechem Biochemicals

Chemical Structure : RA5557

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RA5557 (RA-5557)

货号: PC-38105Not For Human Use, Lab Use Only.

RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.

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生物&药学活性

RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.
RA 5557 reduced pathologically elevated psychosine concentrations (72-86%) in the midbrain and cerebral cortex in twitcher mice.
RA 5557 decreased galactosylceramides by about 70% in midbrain and cerebral cortex in mutant and wild type animals.
RA 5557 significantly decreased several characteristic inflammatory response markers without causing apparent toxicity to myelin-producing cells in wild type and mutant mice.
RA 5557 decreases in vivo galactosphingolipid biosynthesis in murine Krabbe disease.

物理化学性质&存储条件

分子量	529.454
分子式	C20H21F6N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(trifluoromethoxy)ethyl (2R,4R)-2-methyl-4-((3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)oxy)piperidine-1-carboxylate

参考文献

1. Eva Zaccariotto, et al. Biomed Pharmacother. 2022 Mar 12;149:112808.

RA5557 (RA-5557)

生物&药学活性

物理化学性质&存储条件

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RA5557 (RA-5557)

生物&药学活性

物理化学性质&存储条件

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