QAPHA

Chemical Structure : QAPHA

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货号: PC-22259Not For Human Use, Lab Use Only.

QAPHA is a dual function small molecule as both a tubulin polymerization and HDAC inhibitor, induces immunogenic cell death (ICD) through HDAC6 inhibition.

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生物&药学活性

QAPHA is a dual function small molecule as both a tubulin polymerization and HDAC inhibitor, induces immunogenic cell death (ICD) through HDAC6 inhibition.
QAPHA promotes CD4 but not CD8 T cells recruitment in TC-1 tumor infiltrate.
QAPHA antitumor effect do not synergize with anti-PD-1 immunotherapy.
QAPHA effectively inhibits HDAC6, leading to upregulation of HSP90, cytochrome C and caspases, as revealed by proteomic analysis.
QAPHA treatment leads to complete vaccination, elicits potent effector and durable memory antitumor immune responses against lung cancer.
QAPHA treatment promotes the infiltration of M1-polarized macrophages in treated mice, indicating the induction of a pro-inflammatory environment within the tumor.
QAPHA upregulates major histocompatibility complex class II (MHC-II) expression on TC-1 tumor cells both in vitro and in vivo.

物理化学性质&存储条件

分子量	374.40
分子式	C21H18N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(5-((2-cyanoquinolin-4-yl)(methyl)amino)-2-methoxyphenyl)-N-hydroxyacrylamide

参考文献

1. Sarah Ducellier, et al. J Immunother Cancer. 2024 Apr 11;12(4):e007588.

QAPHA

生物&药学活性

物理化学性质&存储条件

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QAPHA

生物&药学活性

物理化学性质&存储条件

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