Procaspase-3 activator 1541B | Procaspases-3 activator

Chemical Structure : Procaspase-3 activator 1541B

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Procaspase-3 activator 1541B (Compound 1541B)

货号: PC-62210Not For Human Use, Lab Use Only.

Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.
Procaspase-3 activator 1541B shows no activition activity for procaspases-6.
Procaspase-3 activator 1541B shows considerable synergy in activating procaspase-3 in vitro combined with PAC-1, stimulates rapid and dramatic maturation of procaspase-3 in multiple cancer cell lines.
Procaspase-3 activator 1541B effectively reduces tumor burden in a murine lymphoma model combined with PAC-1, but not treated alone.

物理化学性质&存储条件

分子量	397.39
分子式	C23H15N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-hydroxy-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide

参考文献

1. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.

2. Botham RC, et al. J Am Chem Soc. 2014 Jan 29;136(4):1312-9.

3. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.

Procaspase-3 activator 1541B (Compound 1541B)

生物&药学活性

物理化学性质&存储条件

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Procaspase-3 activator 1541B (Compound 1541B)

生物&药学活性

物理化学性质&存储条件

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