Pregabalin | VDCC inhibitor | Probechem Biochemicals

Chemical Structure : Pregabalin

CAS No.: 148553-50-8

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Pregabalin (CI-1008, S-(+)-3-isobutylgaba)

货号: PC-61847Not For Human Use, Lab Use Only.

Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).

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25 mg	￥2580	In stock
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生物&药学活性

Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
Pregabalin (CI-1008) prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons.
Pregabalin (CI-1008) does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.

物理化学性质&存储条件

分子量	159.23
分子式	C8H17NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(Aminomethyl)-5-methylhexanoic acid

参考文献

1. Field MJ, et al. Br J Pharmacol. 1997 Aug;121(8):1513-22.

2. Field MJ, et al. J Pharmacol Exp Ther. 1997 Sep;282(3):1242-6.

3. Eutamene H, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):162-7.

Pregabalin (CI-1008, S-(+)-3-isobutylgaba)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pregabalin (CI-1008, S-(+)-3-isobutylgaba)

生物&药学活性

物理化学性质&存储条件

参考文献

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