PI3Kα-IN-5 |CAS:2101744-13-0 Probechem Biochemicals

Chemical Structure : PI3Kα-IN-5

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PI3Kα-IN-5 (PI3Kα inhibitor)

货号: PC-62838Not For Human Use, Lab Use Only.

PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ.

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生物&药学活性

PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ.
PI3Kα-IN-5 displays high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration.
PI3Kα-IN-5 shows good inhibition of tumour growth (86% tumour growth inhibition at 50 mg/kg twice daily orally) in the MCF7 xenograft model in mice.

物理化学性质&存储条件

分子量	363.385
分子式	C17H17N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-amino-6-(imidazo[1,2-a]pyridin-3-yl)-5-methylpyrazin-2-yl)-N,1-dimethyl-1H-1,2,4-triazole-3-carboxamide

参考文献

1. Barlaam B, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):3030-3035.

PI3Kα-IN-5 (PI3Kα inhibitor)

生物&药学活性

物理化学性质&存储条件

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PI3Kα-IN-5 (PI3Kα inhibitor)

生物&药学活性

物理化学性质&存储条件

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