PI3K-IN-16 |CAS:1895876-81-9 Probechem Biochemicals

Chemical Structure : PI3K-IN-16

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PI3K-IN-16 (PI3Kβ/δ inhibitor)

货号: PC-62708Not For Human Use, Lab Use Only.

PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively.

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生物&药学活性

PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively.
PI3K-IN-16 exhibits no significant activity on PI3Kα.
PI3K-IN-16 shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft.

物理化学性质&存储条件

分子量	467.497
分子式	C25H26FN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((8-fluoro-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)methyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

参考文献

1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23.

PI3K-IN-16 (PI3Kβ/δ inhibitor)

生物&药学活性

物理化学性质&存储条件

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PI3K-IN-16 (PI3Kβ/δ inhibitor)

生物&药学活性

物理化学性质&存储条件

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