PD-184352 |CAS:212631-79-3 Probechem Biochemicals

Chemical Structure : PD-184352

CAS No.: 212631-79-3

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PD-184352 (CI-1040, PD184352)

货号: PC-45828Not For Human Use, Lab Use Only.

PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.
PD-184352 reduces pMAPK levels in multiple tumor cells, prevents cell cycle progression and induces G1 block.
PD-184352 suppresses growth of colon tumors in vivo.

物理化学性质&存储条件

分子量	478.6595
分子式	C17H14ClF2IN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 150 mg/mL
Chemical Name/SMILES	Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-

参考文献

1. Sebolt-Leopold JS, et al. Nat Med, 1999, 5(7), 810-816.

2. Davies SP, et al. Biochem J, 2000, 135(1), 95-105.

3. Pellicano F, et al. Leukemia, 2011, 25(7), 1159-1167.

PD-184352 (CI-1040, PD184352)

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物理化学性质&存储条件

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PD-184352 (CI-1040, PD184352)

生物&药学活性

物理化学性质&存储条件

参考文献

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