PBOX-15 | Microtubule inhibitor | Probechem Biochemicals

Chemical Structure : PBOX-15

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PBOX-15 (PBOX15)

货号: PC-60561Not For Human Use, Lab Use Only.

PBOX-15 is a microtubule targeting agent that induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple cancer cells.

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生物&药学活性

PBOX-15 is a microtubule targeting agent that induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple cancer cells.
PBOX-15 radiosensitizes cancer cells in vitro, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours.

物理化学性质&存储条件

分子量	417.464
分子式	C28H19NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(naphthalen-1-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate

参考文献

1. Mulligan JM, et al. Mol Pharmacol. 2006 Jul;70(1):60-70.

2. Verma NK, et al. J Mol Med (Berl). 2008 Apr;86(4):457-69.

3. McElligott AM, et al. Cancer Res. 2009 Nov 1;69(21):8366-75.

4. Maginn EN, et al. Br J Cancer. 2011 Jan 18;104(2):281-9.

PBOX-15 (PBOX15)

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物理化学性质&存储条件

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PBOX-15 (PBOX15)

生物&药学活性

物理化学性质&存储条件

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