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首页-抗体和重组蛋白-Biosimilar Antibody-Obrindatamab
Obrindatamab

Chemical Structure : Obrindatamab

CAS No.: 2069959-72-2

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Obrindatamab (Orlotamab, MGD009)

货号: PC-38833Not For Human Use, Lab Use Only.

Obrindatamab (Orlotamab, MGD009) is a Fc-bearing humanised bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Obrindatamab (Orlotamab, MGD009) is a Fc-bearing humanised bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities.
MGD009 DART protein targets and binds to the cell surface antigen B7-H3, at the same time, the anti-CD3 component binds to human CD3.
MGD009 (Orlotamab) cross-links the T cells to B7-H3-expressing tumor cells, activates and redirects endogenous T cells to kill B7-H3-expressing tumor cells, and inhibits proliferation of B7-H3-expressing tumor cells.
Isotype: IgG1 scFv-h-CH2-CH3(_scFv)_h-CH2-CH3.
Anti-[human CD276 (B7H3, B7-H3, B7RP-2)] and anti-[human CD3E (CD3 epsilon)], monoclonal antibody, bispecific.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

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