Chemical Structure : Nipocalimab
CAS No.: 2211985-36-1
货号: PC-Ab1089Not For Human Use, Lab Use Only.
Nipocalimab (M281, JNJ-80202135) is a fully human IgG1 mAb that selectively bind, saturate, and block the IgG binding site on the endogenous neonatal fragment crystallizable receptor (FcRn). Nipocalimab has potential in treatment of SLE through lowering of pathogenic IgGs and immune complexes. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure
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---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Nipocalimab (M281, JNJ-80202135) is a fully human IgG1 mAb that selectively bind, saturate, and block the IgG binding site on the endogenous neonatal fragment crystallizable receptor (FcRn). Nipocalimab has potential in treatment of SLE through lowering of pathogenic IgGs and immune complexes. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure to the MHC class I moleculethat functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells.
分子量 | ||
分子式 | Human IgG1-Lambda2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Nipocalimab; M281; M 281; JNJ-80202135; Anti-human neonatal Fc receptor for IgG; Anti-human FcRn; Fcgrt gene; Anti-human Brambell receptor; IgG receptor FcRn large subunit p51; 2211985-36-1 |
1. 1, Ling LE, et al. Clin Pharmacol Ther. 2019 Apr;105(4):1031-1039. 2, Roy S, et al. Am J Obstet Gynecol. 2019 May;220(5):498.e1-498.e9. 3, Abdallah HM, et al. Clin Pharmacol Ther. 2020 Feb;107(2):423-434. 4, Timothy T. Kuo, et al. J Clin Immunol. 2010; 30(6): 777–789.
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