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首页-抗体和重组蛋白-Biosimilar Antibody-Nipocalimab
Nipocalimab

Chemical Structure : Nipocalimab

CAS No.: 2211985-36-1

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Nipocalimab (Anti-human FcRn mAb, human IgG1-Lambda2; M281; JNJ-80202135)

货号: PC-Ab1089Not For Human Use, Lab Use Only.

Nipocalimab (M281, JNJ-80202135) is a fully human IgG1 mAb that selectively bind, saturate, and block the IgG binding site on the endogenous neonatal fragment crystallizable receptor (FcRn). Nipocalimab has potential in treatment of SLE through lowering of pathogenic IgGs and immune complexes. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Nipocalimab (M281, JNJ-80202135) is a fully human IgG1 mAb that selectively bind, saturate, and block the IgG binding site on the endogenous neonatal fragment crystallizable receptor (FcRn). Nipocalimab has potential in treatment of SLE through lowering of pathogenic IgGs and immune complexes. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure to the MHC class I moleculethat functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Lambda2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Nipocalimab; M281; M 281; JNJ-80202135; Anti-human neonatal Fc receptor for IgG; Anti-human FcRn; Fcgrt gene; Anti-human Brambell receptor; IgG receptor FcRn large subunit p51; 2211985-36-1

参考文献

1. 1, Ling LE, et al. Clin Pharmacol Ther. 2019 Apr;105(4):1031-1039. 2, Roy S, et al. Am J Obstet Gynecol. 2019 May;220(5):498.e1-498.e9. 3, Abdallah HM, et al. Clin Pharmacol Ther. 2020 Feb;107(2):423-434. 4, Timothy T. Kuo, et al. J Clin Immunol. 2010; 30(6): 777–789.

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