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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-NSC319726
NSC319726

Chemical Structure : NSC319726

CAS No.: 71555-25-4

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NSC319726 (NSC 319726, ZMC1)

货号: PC-45497Not For Human Use, Lab Use Only.

NSC319726 (NSC 319726, ZMC1) is an allele-specific mutant p53 R175 reactivator, restores WT structure and function to the p53(R175) mutant.

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5 mg (Free Sample) ￥180 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC319726 (NSC 319726, ZMC1) is an allele-specific mutant p53 R175 reactivator, restores WT structure and function to the p53(R175) mutant.
NSC319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.

物理化学性质&存储条件

分子量 234.3207
分子式 C11H14N4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 27.5 mg/mL
Chemical Name/SMILES

1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide

参考文献

1. Yu X, et al. Cancer Cell. 2012 May 15;21(5):614-25.

2. Yu X, et al. Oncotarget. 2014 Oct 15;5(19):8879-92.

3. Yu X, et al. Mol Pharmacol. 2017 Jun;91(6):567-575.

4. Shimada K, et al. Cell Chem Biol. 2018 May 17;25(5):585-594.e7.

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