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首页-小分子抑制剂&激动剂-Tyrosine Kinase-VEGFR-NRP1-4
NRP1-4

Chemical Structure : NRP1-4

CAS No.: 1192656-64-6

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NRP1-4 (Neuropilin 1-4)

货号: PC-21310Not For Human Use, Lab Use Only.

NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A.
NRP1-4 (Neuropilin 1-4) is more potent than EG00229 (Cat# PC-42701).
NRP1-4 (Neuropilin 1-4) binds to the serotonin 5-HT7A receptor and histamine H1 receptor with higher affinity compare to NRP1/VEGF-R2, does not have off-target liability at opioid receptors.
NRP1-4 (Neuropilin 1-4) blocks VEGF A–induced increase in dorsal root ganglia excitability.
NRP1-4 (Neuropilin 1-4) attenuates VEGF A-mediated increases in sodium currents.
Inhibition of VEGF A-mediated increase in sodium currents by Neuropilin 1-4 is through NaV1.7.
NRP1-4 (Neuropilin 1-4) blocks VEGF-A-mediated increase in N-type calcium currents.
NRP1-4 (Neuropilin 1-4) reverses VEGF A-mediated increase in N-type calcium currents, prevents VEGF-A–mediated increase in CaV2.2 and NaV1.7 surface expression in rat DRG neurons.
NRP1-4 (Neuropilin 1-4) reverses VEGFA-mediated increase in frequency of spontaneous excitatory postsynaptic currents in the lumbar dorsal horn, NRP1-4 (Neuropilin 1-4) reverses mechanical allodynia following spared nerve injury in rats.

物理化学性质&存储条件

分子量 364.41
分子式 C19H20N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4'-methyl-2'-morpholino-2-(phenylamino)-[4,5'-bipyrimidin]-6(1H)-one

参考文献

1. Harrison J Stratton, et al. Pain. 2023 Jul 1;164(7):1473-1488.

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