NNC 05-2090 hydrochloride |CAS:184845-18-9 Probechem Biochemicals

Chemical Structure : NNC 05-2090 hydrochloride

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NNC 05-2090 hydrochloride (NNC05-2090)

货号: PC-62929Not For Human Use, Lab Use Only.

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.

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生物&药学活性

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.
NNC 05-2090 displays >10 fold selectivity over mGAT1, mGAT3 and mGAT4, also has alpha 1- and D2-receptor affinity of 266 and 1632 nM, respectively.
NNC 05-2090 inhibits 3HGABA uptake into synaptosomes from cerebral cortex with IC50 of 4.4 uM.
NNC 05-2090 significantly reduces generalized seizure severity and afterdischarge duration in rats.

物理化学性质&存储条件

分子量	451.01
分子式	C27H31ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

参考文献

1. Thomsen C, et al. Br J Pharmacol. 1997 Mar;120(6):983-5.

2. Dalby NO, et al. Epilepsy Res. 1997 Jul;28(1):51-61.

3. Jinzenji A, et al. J Pharmacol Sci. 2014;125(2):217-26.

NNC 05-2090 hydrochloride (NNC05-2090)

生物&药学活性

物理化学性质&存储条件

参考文献

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NNC 05-2090 hydrochloride (NNC05-2090)

生物&药学活性

物理化学性质&存储条件

参考文献

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