NC-043 |CAS:1053172-87-4 Probechem Biochemicals

Chemical Structure : NC-043

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NC-043 (NC043;15-Oxospiramilactone)

货号: PC-61798Not For Human Use, Lab Use Only.

NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association.

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1 g		Get quote

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生物&药学活性

NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association.
NC-043 decreases the mRNA and/or protein expression of Wnt target genes Axin2, Cyclin D1 and Survivin in SW480 cells, inhibits anchorage-independent growth and xenograft tumorigenesis in vitro and in vivo.
NC-043 inhibits canonical Wnt signaling downstream of β-catenin stability, causes G2/M arrest and inhibits colon cancer cell growth.

物理化学性质&存储条件

分子量	330.42
分子式	C20H26O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Atis-16-en-20-oic acid, 7,18-dihydroxy-15-oxo-, 20,18-lactone, (4α,5β,7α,8α,9β,10α,12α)-

参考文献

1. Wang W, et al. Cell Res. 2011 May;21(5):730-40.

2. Yan M, et al. Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197.

3. He X, et al. Cell Discov. 2017 Jan 31;3:17003.

NC-043 (NC043;15-Oxospiramilactone)

生物&药学活性

物理化学性质&存储条件

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NC-043 (NC043;15-Oxospiramilactone)

生物&药学活性

物理化学性质&存储条件

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