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首页-抗体和重组蛋白-Biosimilar Antibody-Mavrilimumab
Mavrilimumab

Chemical Structure : Mavrilimumab

CAS No.: 1085337-57-0

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Mavrilimumab (Anti-human GM-CSF mAb, human IgG1-Lambda2; KPL-301; CAM3001)

货号: PC-Ab1075Not For Human Use, Lab Use Only.

Mavrilimumab (KPL-301, CAM3001) is a monoclonal antibody to GM-CSF receptor-α chain, and competitive antagonist of GM-CSF signaling. Mavrilimumab also is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVI

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mavrilimumab (KPL-301, CAM3001) is a monoclonal antibody to GM-CSF receptor-α chain, and competitive antagonist of GM-CSF signaling. Mavrilimumab also is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVID-19 patients, specifically those patients with pneumonia.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Lambda2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Mavrilimumab; KPL-301; CAM3001; Granulocyte macrophage colony-stimulating factor; Anti human GM-CSF.

参考文献

1. 1, Nair JR, et al. Expert Opin Biol Ther. 2012 Dec;12(12):1661-8. 2, Burmester GR, et al. Ann Rheum Dis. 2011 Sep;70(9):1542-9. 3, Burmester GR, et al. Ann Rheum Dis. 2013 Sep 1;72(9):1445-52. 4, De Luca G, et al. Lancet Rheumatol. 2020 Aug;2(8):e465-e473. 5, Bhatt K, et al. Infect Chemother. 2021 Mar;53(1):1-12.

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