Chemical Structure : Mavrilimumab
CAS No.: 1085337-57-0
货号: PC-Ab1075Not For Human Use, Lab Use Only.
Mavrilimumab (KPL-301, CAM3001) is a monoclonal antibody to GM-CSF receptor-α chain, and competitive antagonist of GM-CSF signaling. Mavrilimumab also is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVI
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Mavrilimumab (KPL-301, CAM3001) is a monoclonal antibody to GM-CSF receptor-α chain, and competitive antagonist of GM-CSF signaling. Mavrilimumab also is a monoclonal antibody (mAb) that may be helpful in some cases with COVID-19. Mavrilimumab antagonizes the action of GM-CSF and decreases the hyperinflammation associated with pneumonia in COVID-19, therefore strengthening the rationale that mavrilimumab when added to the standard protocol of treatment could improve the clinical outcomes in COVID-19 patients, specifically those patients with pneumonia.
分子量 | ||
分子式 | Human IgG1-Lambda2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Mavrilimumab; KPL-301; CAM3001; Granulocyte macrophage colony-stimulating factor; Anti human GM-CSF. |
1. 1, Nair JR, et al. Expert Opin Biol Ther. 2012 Dec;12(12):1661-8. 2, Burmester GR, et al. Ann Rheum Dis. 2011 Sep;70(9):1542-9. 3, Burmester GR, et al. Ann Rheum Dis. 2013 Sep 1;72(9):1445-52. 4, De Luca G, et al. Lancet Rheumatol. 2020 Aug;2(8):e465-e473. 5, Bhatt K, et al. Infect Chemother. 2021 Mar;53(1):1-12.
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