MLT-985 | MALT1 inhibitor | Probechem Biochemicals

Chemical Structure : MLT-985

CAS No.: 1832576-25-6

加入收藏

MLT-985 (MLT985, MV088428)

货号: PC-49482Not For Human Use, Lab Use Only.

MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).

规格	价格	库存
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MLT-985 (MLT985) is a potent, highly selective allosteric MALT1 inhibitor with biochemical IC50 of 3 nM, and 20 nM in IL-2 reporter gene assay (Jurkat T cells).
MLT-985 showed excellent selectivity against a panel of 23 human proteases (all IC50>10 uM), including cysteine proteases such as Caspase 3 and Cathepsin B, C, K, L and S.
MLT-985 inhibits human PBMC IL-2 release with IC50 of 0.5 uM.
MLT-985 demonstrated activity in cellular ABC-DLBCL models that is consistent with potent and selective inhibition of MALT1, suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells.
MLT-985 demonstrated tumor regression in the CARD11-mutant ABC-DLBCL xenograft model OCILy3.

物理化学性质&存储条件

分子量	448.27
分子式	C17H15Cl2N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea

参考文献

1. Jean Quancard, et al. J Med Chem. 2020 Dec 10;63(23):14594-14608.

MLT-985 (MLT985, MV088428)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MLT-985 (MLT985, MV088428)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.