MLT-231 | MALT1 inhibitor | Probechem Biochemicals

Chemical Structure : MLT-231

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MLT-231 (MLT231)

货号: PC-49480Not For Human Use, Lab Use Only.

MLT-231 (MLT231) is a highly potent, selective, allosteric MALT1 inhibitor with biochemical IC50 of 9 nM, inhibits MALT1 cleavage of the BCL10 substrate with IC50 of 0.16 uM.

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生物&药学活性

MLT-231 (MLT231) is a highly potent, selective, allosteric MALT1 inhibitor with biochemical IC50 of 9 nM, inhibits MALT1 cleavage of the BCL10 substrate with IC50 of 0.16 uM.
MLT-231 exhibited high MALT1 selectivity over other proteases.
MLT-231 inhibited cellular proliferation (low micromolar range) and cleavage of MALT1 substrates in ABC-DLBCL.
MLT-231 (100 mg/kg) dose-dependently reduced the anti-DNP IgM and IgG responses induced by 2,4-dinitrophenol (DNP) in mice, blocked T cell-dependent B cell responses.
MLT-231 (100 mg/kg, oral bid schedule for 2 weeks) exhibited antitumor efficacy in OCI-Ly10 ABC-DLBCL type xenograft models.

物理化学性质&存储条件

分子量	469.853
分子式	C19H19ClF3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-Chloro-7-((3S,5S)-3,5-dimethylmorpholino)pyrazolo[1,5-a]pyrimidin-6-yl)-3-(2-(trifluoromethyl)pyridin-4-yl)urea

参考文献

1. Carole Pissot Soldermann, et al. J Med Chem. 2020 Dec 10;63(23):14576-14593.

MLT-231 (MLT231)

生物&药学活性

物理化学性质&存储条件

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MLT-231 (MLT231)

生物&药学活性

物理化学性质&存储条件

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