ML-240 |CAS:1346527-98-7 Probechem Biochemicals

Chemical Structure : ML-240

CAS No.: 1346527-98-7

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ML-240 (ML 240;ML-240)

货号: PC-45717Not For Human Use, Lab Use Only.

ML240 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ML240 is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM).
ML240 blocks degradation of p97-dependent proteasome substrate with an IC50 of 0.9 uM.
ML240 induces caspases 3 and 7 and potently blocked proliferation in HCT15 and SW403 cells.

物理化学性质&存储条件

分子量	396.4445
分子式	C23H20N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 16.5 mg/mL
Chemical Name/SMILES	4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-

参考文献

1. Chou TF, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Chou TF, et al. ChemMedChem. 2013 Feb;8(2):297-312.

3. Bastola P, et al. Mol Oncol. 2016 Dec;10(10):1559-1574.

ML-240 (ML 240;ML-240)

生物&药学活性

物理化学性质&存储条件

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ML-240 (ML 240;ML-240)

生物&药学活性

物理化学性质&存储条件

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