MEISi-1 | MEIS1 inhibitor | Probechem Biochemicals

Chemical Structure : MEISi-1

CAS No.: 446306-43-0

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MEISi-1 (MEIS inhibitor 1)

货号: PC-20504Not For Human Use, Lab Use Only.

MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.

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25 mg	￥1580	In stock
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生物&药学活性

MEISi-1 (MEIS inhibitor 1) is a specific small molecule inhibitor of MEIS1 (Meis1), significantly inhibits MEIS1 protein activity in MEIS-luc reporter assays at 0.1 uM, modulates hematopoietic stem cell (HSC) activity.
MEISi-1 (0.1-10 uM) induced MEIS dependent hematopoietic stem cell maintenance and self-renewal.
MEISi-1 downregulated MEIS target gene expression (Hif-1α, Hif-2α, and HSC quiescence modulators Foxo3, Nfat5, and Ptpmt1).
MEISi-1 functionally inhibited MEIS in vivo, induces c-Kit+ cell, Sca1+ cell, CD150+cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48-HSC content.
MEISi-1 was effective in vivo as evident by induced HSC content in the murine bone marrow and downregulation of expression of MEIS target genes.

物理化学性质&存储条件

分子量	388.47
分子式	C24H24N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=CC(C)=C1C)C2=CC=C(OCC(NCC3=CC=CC=C3)=O)C=C2

参考文献

1. Raife Dilek Turan, et al. Sci Rep. 2020 May 14;10(1):7994.

MEISi-1 (MEIS inhibitor 1)

生物&药学活性

物理化学性质&存储条件

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MEISi-1 (MEIS inhibitor 1)

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物理化学性质&存储条件

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