MCU-i11

Chemical Structure : MCU-i11

CAS No.: 902903-59-7

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货号: PC-73143Not For Human Use, Lab Use Only.

MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.

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5 mg	￥2780	In stock
10 mg	￥4580	In stock
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生物&药学活性

MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i11 directly binds a specific cleft in MICU1 (Kd=2.9 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i11 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.

物理化学性质&存储条件

分子量	532.615
分子式	C28H28N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-1(2H)-acetamide, 7-acetyl-N-(4-ethoxyphenyl)-3,4,5,6,7,8-hexahydro-2,4-dioxo-3-(phenylmethyl)-

参考文献

1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

MCU-i11

生物&药学活性

物理化学性质&存储条件

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MCU-i11

生物&药学活性

物理化学性质&存储条件

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