MC3343 | DNMT inhibitor | Probechem Biochemicals

Chemical Structure : MC3343

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MC3343 (MC-3343, MC 3343)

货号: PC-35290Not For Human Use, Lab Use Only.

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively.

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生物&药学活性

MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively.
MC3343 displays increased potency against DNMT1 compared with RG-108 and SGI-1027.
MC3343 efficiently inhibits OS cell proliferation and induces osteoblastic differentiation, induces dose- and time-dependent decreases in DNMT1, DNMT3a and DNMT3b protein levels in Saos-2 OS cells.
MC3343 displays synergistic effects with doxorubicin and cisplatin in vivo, reduces patient-derived xenograft OS growth and induces differentiation.

物理化学性质&存储条件

分子量	461.529
分子式	C27H23N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide

参考文献

1. Manara MC, et al. Mol Cancer Ther. 2018 Jun 29. pii: molcanther.0818.2017.

MC3343 (MC-3343, MC 3343)

生物&药学活性

物理化学性质&存储条件

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MC3343 (MC-3343, MC 3343)

生物&药学活性

物理化学性质&存储条件

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