MC1575 |CAS: 615252-74-9 Probechem Biochemicals

Chemical Structure : MC1575

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MC1575 (MC-1575)

货号: PC-63087Not For Human Use, Lab Use Only.

MC1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B.

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生物&药学活性

MC1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B.
MC1575 exhibits a dose-dependent antiproliferative effect and induces cell cycle arrest although this blockade occurred at a different level than TSA.
MC1575 increases p21(waf1/CIP1) mRNA levels and induces ERbeta gene expression.
MC1575 also suppress IL-8 expression in human melanoma cells.

物理化学性质&存储条件

分子量	330.77
分子式	C17H15ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-((E)-3-(3-chlorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

参考文献

1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53.

2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.

3. Venza I, et al. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.

MC1575 (MC-1575)

生物&药学活性

物理化学性质&存储条件

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MC1575 (MC-1575)

生物&药学活性

物理化学性质&存储条件

参考文献

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