M3541 | ATM inhibitor | Probechem Biochemicals

Chemical Structure : M3541

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M3541 (M 3541)

货号: PC-73375Not For Human Use, Lab Use Only.

M3541 (M 3541) is a novel potent, selective and ATP-competitive ATM kinase inhibitor with IC50 of 0.25 nM (ATP, 10 uM).

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生物&药学活性

M3541 (M 3541) is a novel potent, selective and ATP-competitive ATM kinase inhibitor with IC50 of 0.25 nM (ATP, 10 uM).
M3541 displays a good margin of selectivity (>60-fold) against the closely related PIKK family members with DNA-PK, PI3K isoforms, mTOR, and ATR.
M3541 inhibits the phosphorylation of ATM as well as its cellular substrates CHK2, KAP1, and p53 in a concentration-dependent manner in A549 cells.
M3541 inhibits double strand break repair and sensitizes cancer cells to radiation.
M3541 suppresses ATM pathway activity and potentiates radiation efficacy in xenograft models of human cancer, synergizes with topoisomerase and PARP inhibitors.

物理化学性质&存储条件

分子量	428.427
分子式	C23H17FN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-fluoro-4-(7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)benzonitrile

参考文献

1. Astrid Zimmermann, et al. Mol Cancer Ther. 2022 Apr 11;molcanther.0934.2021.

M3541 (M 3541)

生物&药学活性

物理化学性质&存储条件

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M3541 (M 3541)

生物&药学活性

物理化学性质&存储条件

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