LSH-A54 | class I HDAC inhibitor | Probechem Biochemicals

Chemical Structure : LSH-A54

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LSH-A54 (class I HDAC inhibitor)

货号: PC-38119Not For Human Use, Lab Use Only.

LSH-A54 is a potent, class I selective HDAC inhibitor with IC50 of 26.2 nM (HDAC1) and 59.3 nM (HDAC2).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

LSH-A54 is a potent, class I selective HDAC inhibitor with IC50 of 26.2 nM (HDAC1) and 59.3 nM (HDAC2).
LSH-A54 displays no significant inhibition against HADC3/6 (IC50>10 uM).
LSH-A54 exhibits antiproliferative properties against breast cancer cell lines T-47D (IC50=1.58 uM), MCF-7 (IC50=1.32 uM) and BT-474 (IC50=2.55 uM).
LSH-A54 attenuates cell migration significantly in wound healing assay and comparably to the pan-HDACi vorinostat, whereas the HDAC1-3 selective HDACi entinostat has no significant effect on cell migration.
LSH-A54 reduced the number of colonies significantly in clonogenic survival assay compared to entinostat and showed comparable activity to pan-HDACi vorinostat.

物理化学性质&存储条件

分子量	578.717
分子式	C34H38N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((2-amino-5-(pyridin-4-yl)phenyl)carbamoyl)benzyl)-N-(2-(tert-butylamino)-2-oxoethyl)-4-(dimethylamino)benzamide

参考文献

1. Schäker-Hübner L, et al. ChemMedChem. 2022 Jan 24:e202100755.