LCS-1.34 |CAS:24725-65-3 Probechem Biochemicals

Chemical Structure : LCS-1.34

CAS No.: 24725-65-3

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LCS-1.34 (LCS1.34)

货号: PC-62033Not For Human Use, Lab Use Only.

LCS-1.34 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.1 uM.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
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生物&药学活性

LCS-1.34 is a small molecule that inhibits growth of human lung adenocarcinoma cells harboring mutations in EGFR or KRAS with IC50 of 0.1-1.1 uM.
Superoxide dismutase 1 (SOD1) is the most likely target o, LCS-1.34 inhibits SOD1 in a dose-dependent manner with IC50 of 1.07 uM.
LCS-1.34 inhibits MAPK and PI3-kinase pathways, DNA synthesis and induces apoptosis.

物理化学性质&存储条件

分子量	309.955
分子式	C10H4Cl4N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,5-dichloro-2-(2,4-dichlorophenyl)pyridazin-3(2H)-one

参考文献

1. Somwar R, et al. J Biomol Screen. 2009 Dec;14(10):1176-84.

2. Somwar R, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80.

LCS-1.34 (LCS1.34)

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LCS-1.34 (LCS1.34)

生物&药学活性

物理化学性质&存储条件

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