KY-1220 |CAS:292168-79-7 Probechem Biochemicals

Chemical Structure : KY-1220

CAS No.: 292168-79-7

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KY-1220 (KY1220)

货号: PC-70091Not For Human Use, Lab Use Only.

KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM).
KY-1220 dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells.
KY-1220 reduces β-catenin and pan-Ras protein levels via polyubiquitin-dependent proteasomal degradation, consequently inhibits the activities of both ERK and Akt in various CRC cell lines.
KY-1220 efficiently inhibits proliferation and transformation in HCT15, SW480, D-WT and D-MT CRC cells.

物理化学性质&存储条件

分子量	314.319
分子式	C14H10N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-5-((1-(4-nitrophenyl)-1H-pyrrol-2-yl)methylene)-2-thioxoimidazolidin-4-one

参考文献

1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.

2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.

KY-1220 (KY1220)

生物&药学活性

物理化学性质&存储条件

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KY-1220 (KY1220)

生物&药学活性

物理化学性质&存储条件

参考文献

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