KT-195 |CAS:1402612-58-1 Probechem Biochemicals

Chemical Structure : KT-195

CAS No.: 1402612-58-1

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KT-195 (ML-295, ML295, KT195)

货号: PC-61840Not For Human Use, Lab Use Only.

KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

KT-195 (ML 295) is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM.
KT-195 displays negligible activity against other serine hydrolases such as DAGLβ.
KT-195 induce a significant accumulation of 2-AG in Neuro2a cells.
KT-195 inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−.
KT-195 inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak.

物理化学性质&存储条件

分子量	438.5
分子式	C27H26N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone

参考文献

1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.

2. Yun B, et al. J Biol Chem. 2014 Jan 17;289(3):1491-504.

KT-195 (ML-295, ML295, KT195)

生物&药学活性

物理化学性质&存储条件

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KT-195 (ML-295, ML295, KT195)

生物&药学活性

物理化学性质&存储条件

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