KHS101 |CAS:1262770-73-9 Probechem Biochemicals

Chemical Structure : KHS101

CAS No.: 1262770-73-9

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KHS101 (KHS-101)

货号: PC-62044Not For Human Use, Lab Use Only.

KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

KHS101 (KHS-101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM).
KHS101 works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression.
KHS101 significantly increases neuronal differentiation in rats in vivo.

物理化学性质&存储条件

分子量	339.46
分子式	C18H21N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

参考文献

1. Wurdak H, et al. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7.

2. Guo Y, et al. ACS Chem Biol. 2013 Mar 15;8(3):626-35.

KHS101 (KHS-101)

生物&药学活性

物理化学性质&存储条件

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KHS101 (KHS-101)

生物&药学活性

物理化学性质&存储条件

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