KDOBA67 | KDM6A/B inhibitor | Probechem Biochemicals

Chemical Structure : KDOBA67

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KDOBA67 (KDOBA 67)

货号: PC-72453Not For Human Use, Lab Use Only.

KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines.

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生物&药学活性

KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines.
KDOBA67 displayed in vitro inhibitory activity in the low micromolar range with IC50 values of 2 to 5 uM in various chordoma cell lines, leading to induction of apoptosis.
H3K27 demethylase inhibition via KDOBA67 alters chromatin state at TBXT and inhibits its expression.
TBXT was a KDM6A/B target gene, and chromatin changes at TBXT following KDOBA67 treatment were associated with a reduction in TBXT protein levels.
KDOBA67 treatment downregulated expression of a network of transcription factors critical for chordoma survival and upregulated pathways dominated by ATF4-driven stress and proapoptotic responses.

物理化学性质&存储条件

分子量	361.449
分子式	C21H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-(pyridin-3-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)ethan-1-ol

参考文献

1. Lucia Cottone, et al. Cancer Res. 2020 Oct 15;80(20):4540-4551.

KDOBA67 (KDOBA 67)

生物&药学活性

物理化学性质&存储条件

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KDOBA67 (KDOBA 67)

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物理化学性质&存储条件

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