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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-KAI-407
KAI-407

Chemical Structure : KAI-407

CAS No.: 1513879-18-9

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KAI-407 (KAI407)

货号: PC-61697Not For Human Use, Lab Use Only.

KAI-407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KAI-407 is a potent, non-8-aminoquinoline antamalarial compound that kills Plasmodium cynomolgi early dormant liver stage parasites (IC50=0.69 uM for hypnozoites, IC50=0.64 uM for developing liver stages); prevents blood stage parasitemia in mice (100mg/kg); orally bioavailable.

物理化学性质&存储条件

分子量 421.383
分子式 C22H14F3N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide

参考文献

1. Zeeman AM, et al. Antimicrob Agents Chemother. 2014;58(3):1586-95.

2. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.

3. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

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