JN-KI3

Chemical Structure : JN-KI3

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货号: PC-23729Not For Human Use, Lab Use Only.

JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM).

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250 mg		Get quote

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生物&药学活性

JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM).
JN-KI3 selectively anti-proliferate against hematologic cancer cells.
JN-KI3 induces apoptosis of hematologic cancer cells with selective inhibition on PI3K/AKT signaling pathway.
JN-KI3 effectively suppressed C5a-induced Akt phosphorylation in a concentration-dependent manner, with no discernible toxicity observed in RAW264.7 cells.
JN-KI3 inhibited the infiltration of inflammatory cells and the expression of T-helper type 2 cytokines in bronchoalveolar lavage fluid in ovalbumin-induced murine asthma model.

物理化学性质&存储条件

分子量	477.00
分子式	C28H29ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(3-((4-chlorobenzyl)amino)-2-hydroxypropoxy)-2-methyl-1-(p-tolyl)-1H-indol-3-yl)ethan-1-one

参考文献

1. Zhu J, et al. J Adv Res. 2021 Apr 20;36:1-13.

JN-KI3

生物&药学活性

物理化学性质&存储条件

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JN-KI3

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物理化学性质&存储条件

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